Gea introduces industrial-scale equipment for vaccines and blood plasma

Technology for blood plasma fractionation and vaccine production

The photo shows the final formulation process. This process has two steps. An Ultra-Diafiltration and the following formulation step. The product is Immunoglobulin. (Photo: BLICKPUNKT PHOTODESIGN/Daniel Bödeker)

GEA has developed numerous innovative improvements to both blood fractionation and vaccine production and brought them to the global market by applying first-class engineering.

Fractionating human blood plasma yields purified and concentrated proteins from which drugs or vaccines are then developed. The blood plasma fractionation process is complex and requires in-depth knowledge of both the procedure and the specific equipment needed to achieve high yields in a cost-effective timeframe. In the fight against coronavirus, for example, the administration of antibodies to counter Sars-CoV-2 is a promising treatment option. Once someone has been infected with a virus and recovers, their blood is rich with antibodies. Like a vaccine, giving antibody infused blood plasma to a sick patient could speed up their recovery. The advantage, especially for immunocompromised patients, is that the antibodies have already been produced. The downside, however, is the absolute requirement for a sufficient number of willing donors.

However, whether a vaccine induces antibody production or they’re obtained from blood plasma, both approaches ultimately have one thing in common. Once the laboratory work and clinical tests have been completed, full-scale production must be expedited to manufacture the largest possible quantities. GEA, the globally active mechanical and plant engineering company with a long history of vaccine and blood fractionation expertise, is ready to quickly transform developments made by pharmaceutical and biotechnology companies into marketable processes and systems.

GEA technology for blood plasma fractionation
Blood fractionation refers to the process of separating the plasma obtained from blood into its individual components. Plasma is the liquid part of the blood and accounts for about 55% of the total volume. It consists mainly of water and contains small amounts of dissolved minerals, salts, iron, nutrients and proteins. It serves as a transport and storage medium for erythrocytes (red blood cells), leukocytes (white blood cells) and thrombocytes (blood platelets).

The design, construction and installation of an integrated fractionation plant is an extremely complex and challenging undertaking. It’s not just a matter of simply connecting various unit operations, it also requires the precise control of parameters including pH, ethanol content and temperature. Equally important is the use of suitable virus inactivation steps and the complete automation and validation of the entire system. With individual machines or modules that can be combined and automated to ensure maximum flexibility, high yields, efficient and reliable operation for a long service life, GEA is committed to developing and supplying customer-oriented solutions. The company’s extensive experience in plant-specific process implementation has been proven during the last 20 years with the successful completion of countless projects for many clients.

Technologies for global vaccine production
GEA is also a world leader in the design and configuration of microbial and cell fermentation systems for the vaccine industry. Supplying standalone modular technologies that can be combined to form an entire production plant, these GEA solutions are based on extensive expertise in cell culture systems, cell separators, homogenization plant and filtration units.

Furthermore, GEA’s spray- and freeze-drying technologies help innovative technology companies to develop temperature-stable blood products and vaccine preparations that have a long shelf-life and do not require refrigeration, making them easier to transport to hard-to-reach and remote areas.

For many years, GEA has been working closely with the world’s largest vaccine manufacturers. GEA is also an active partner of many other companies in the Developing Countries Vaccine Manufacturers Network (DCVMN) around the world to support the safe and reliable production of cost-effective vaccines.

The Covid-19 pandemic led to the country-wide lockdown on 25 March 2020. It will be two years tomorrow as I write this. What have we learned in this time? Maybe the meaning of resilience since small companies like us have had to rely on our resources and the forbearance of our employees as we have struggled to produce our trade platforms.

The print and packaging industries have been fortunate, although the commercial printing industry is still to recover. We have learned more about the digital transformation that affects commercial printing and packaging. Ultimately digital will help print grow in a country where we are still far behind in our paper and print consumption and where digital is a leapfrog technology that will only increase the demand for print in the foreseeable future.

Web analytics show that we now have readership in North America and Europe amongst the 90 countries where our five platforms reach. Our traffic which more than doubled in 2020, has at times gone up by another 50% in 2021. And advertising which had fallen to pieces in 2020 and 2021, has started its return since January 2022.

As the economy approaches real growth with unevenness and shortages a given, we are looking forward to the PrintPack India exhibition in Greater Noida. We are again appointed to produce the Show Daily on all five days of the show from 26 to 30 May 2022.

It is the right time to support our high-impact reporting and authoritative and technical information with some of the best correspondents in the industry. Readers can power Packaging South Asia’s balanced industry journalism and help sustain us by subscribing.

– Naresh Khanna

Subscribe Now


Please enter your comment!
Please enter your name here